The purpose of this study is to determine whether daily transdermal nicotine (patch) will have a positive effect on early memory impairment in participants diagnosed with MCI. This study, which will take place at multiple sites across the U.S., will consist of 12 visits over a 2-year period.
Healthy, non-smoking adults, age 55+, will have extensive memory & cognitive testing as part of the screening process. Those who meet the study qualifications will be placed on either daily nicotine or placebo (inactive ingredient) patches. Some study sites will additionally conduct an MRI (brain scan) in addition to the regular study procedures.
Participants are required to have a study partner who will accompany them to each appointment. This partner may be a family member, close friend, or caregiver. This person must be someone that knows the participant well and spends a minimum of 10 hours a week with them. This is necessary in order for the partner to give the research staff feedback on the participant’s memory, health, & functioning throughout the study.